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Sustained local delivery of MMP9-targeting small interfering RNA (siMMP9) has been achieved through hydrogel loading, which significantly improved diabetic wound closure by silencing MMP9 (Lan et al., 2021)

Future intervention studies should use placebo-controlled designs with identical excipients to eliminate this bias

Adults aged 65 years accounted for 51%-62% of hospitalizations and 84%-87% of deaths

Smaller strengths suit lower-dose research

Due to its acidic nature, localized burning or welt-like reactions have been observed in some models following subcutaneous placement