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Studies using single oral doses of metformin HCl tablets 500 mg to 1,500 mg, and 850 mg to 2,550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination

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Clinical trials show no direct hair loss from the medication itself, but up to 10% of patients experience temporary shedding during treatment cycles

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Furthermore, OH generated via the Fenton reaction oxidize polyunsaturated fatty acids in the sperm membrane, producing malondialdehyde (MDA)

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