Early research, including a study from Tokyo Medical University, reported modest weight reduction in participants supplementing with this strain over a 12-week period
However, these do have to be prescribed and administered by a healthcare professional, and are more likely to be given to people who have lifelong conditions affecting their ability to absorb B12 or who are at higher risk of consistent deficiency
But the science is more complicated
As a result, underlying mechanisms of them are sequentially connected, even though their primary goal is different respectively
By activating the GLP-1 receptor, GLP-1RA enhances insulin secretion and inhibits glucagon secretion to lower blood glucose, ingeniously suppressing appetite, increasing satiety, and delaying gastric emptying, thus achieving weight reduction (Torekov et al., 2011
According to the FDA's approval, the eligibility criteria are as follows: For Adults: A Body Mass Index (BMI) of 30 kg/m or greater (defined as obesity), OR a BMI of 27 kg/m or greater (defined as overweight) with at least one weight-related comorbidity, such as high blood pressure, type 2 diabetes, or high cholesterol
