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Future cohort studies should consider the risk for reverse causation introduced by pancreatic cancer-related diabetes where the diabetes is paraneoplastic in response to the pancreatic tumor 46

The pharmaceutical version extends that to 6 days through deliberate structural design

Expect a gradual trend, especially as doses are increased slowly to improve tolerability

But there are some pretty important reasons, like cost savings, minimizing side effects, preventive benefits, or a combination

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And being at the edge means increased risk of bloating , nausea, and other gastrointestinal side effects that make the experience unpleasant