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[1] [2] The most commonly reported side effects in clinical trials were gastrointestinal, including nausea (occurring in 12-29% of patients), diarrhea, vomiting, constipation, and abdominal discomfort

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UnitedHealth Group/OptumRx monetizes claims data as a secondary IP stream, selling analytical products back to the same manufacturers whose formulary positioning it controls

Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests

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