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Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimers disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial

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Subjects in the HC group were individuals aged over 18 years, without an epilepsy diagnosis, free from known diseases, and not undergoing pharmacological treatment

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Additionally, in Europe, the European Medicines Agency (EMA) approved Wegovy in 2022, and countries such as the UK have integrated it into national obesity programs, where demand far exceeded supply in 2024 (MHRA)

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