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Most patients report noticeable changes in hunger signals and appetite intensity between 24 and 72 hours after administration

Over 86% of the semaglutide group achieved weight loss of 5% or more, a standard clinical threshold for improving metabolic health

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Keywords: pediatric obesity, GLP-1 receptor agonists, semaglutide, adolescent weight management, pharmacotherapy, long-term safety, health equity, obesity treatment Introduction The global pediatric obesity epidemic represents one of the most pressing public health challenges of the 21st century