Research Applications DSIP research has investigated its effects on sleep architecture modulation, particularly the enhancement of delta (slow-wave) sleep
These differences may be based in biology, such as chromosomal or hormonal differences related to reproductive history 343 (i.e., sex differences), or in how social and cultural factors are distributed among or are experienced by men and women (i.e., gender differences), or a combination of these
PMID 36723855
M.VietaE.et al (2017)
These variations significantly influence the role of GLP-1 in regulating islet function and glucose homeostasis.131 Research indicates that the expression level of GLP-1R on -cells is relatively low.131 Although GLP-1Rs are present, they are limited in number, making the direct inhibitory effect of GLP-1 on -cells relatively weak.247 The primary action often occurs through indirect mechanisms, such as insulin and somatostatin.244 Conversely, the expression level of GLP-1R on -cells is relatively high.248 GLP-1 can effectively bind to receptors on -cells, stimulating the secretion of somatostatin.248 As a broad-spectrum inhibitory hormone, somatostatin can effectively inhibit glucagon secretion from -cells and insulin secretion from -cells.249,250 Relevant studies suggest that the expression of GLP-1R on -cells is crucial for GLP-1s regulation of somatostatin secretion and the overall inhibitory effect on glucagon.248,251,252 This mechanism is particularly evident in the use of GLP-1-based drugs, such as GLP-1RAs, in the treatment of T2DM
Theranostics 8 , 14811493 (2018)
