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This creates a vicious cycle: the immune response causes oxidative stress, and the oxidative stress triggers even more immune activity

Pioglitazone Pioglitazone is both a PPAR and PPAR agonist with hypoglycemic activity and an insulin-sensitizing role.Pioglitazone is the only drug of the TZD class still commonly used in clinical practice

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doi: 10.1016/j.fochms.2022.100133 15 KannoTNakajimaTMiyakoKEndoY

Genetic context alone does not determine treatment success

The appetite suppression is proof that the medication is working, even if the scale hasn't shifted yet