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The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

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Obesity, a leading risk factor for diabetes, also is accelerating in developing countries, even while it has plateaued in high-income countries, according to another study published this week in Nature