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Except for the seminal study of Cox et al

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The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60

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Nef-Induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction

The injections work by correcting deficiency, not by super-charging normal physiology