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If deemed clinically appropriate, eligible participants are provided access to GLP-1 medications like Wegovy and Ozempic

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These findings suggest that a mechanism similar to that observed in mice [10] is at work in humans and that combining metformin with DPP-4 inhibitors appears to be a rational way of enhancing GLP-1 signalling in pancreatic beta cells

These effects remained directionally consistent in subgroup and sensitivity analyses

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10.1007/s11120-005-8425-1 30 MicheletL.ZaffagniniM.MarchandC.CollinV.DecottigniesP.TsanP.et al