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Docetaxel/androgen deprivation therapy (ADT) combined with 150 mg/day of lycopene resulted in dose-limiting toxicity in 1 of 12 cases, establishing it as the MTD

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GLP-1 agonists work through distinct mechanismsenhancing glucose-dependent insulin secretion, suppressing glucagon, delaying gastric emptying, and promoting central satiety signaling

In the context of FSH signaling, MI amplifies granulosa cell responsiveness, facilitating follicular growth, estradiol synthesis, and ovulation

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For example, SCFA receptors such as GPCR41 and GPCR43, medium and long-chain fatty acid receptors GPCR40 and GPCR120, and the chenodeoxycholic acid receptor farnesoid X receptor (FXR) expressed in intestinal cells and other tissues have been associated with the modulation of various host-specific metabolic processes, including the inhibition of insulin secretion, reduction of non-esterified fatty acid release, suppression of bile acid synthesis, and regulation of fatty acid metabolism 5