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Abstract Immune checkpoint blockade therapy has revolutionized cancer treatment, but resistance remains prevalent, often due to dysfunctional tumor-infiltrating lymphocytes

It is known that the human gut microbiome is different and stratified, not continuous, in the population

IFN- also elevates mitochondrial reactive oxygen species, presumably via the STAT1/NF-B/NOS2 pathway

Combining them could provide both a systemic and localized boost to the bone repair process

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Sildenafil and furosemide nanoparticles as a novel pharmacological treatment for acute renal failure in rats