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The association between NOS3 genetic variants and HAPE susceptibility appears to be complex and varies across different geographical and ethnic populations

It more comprehensively improves systemic oxidative stress

Studies in diabetic animal models show that antioxidant treatment with N-acetyl cysteine and -tocopherol dramatically reduces oxidative stress, increases antibiotic sensitivity of biofilms, and promotes proper collagen deposition and remodeling

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doi: 10.1002/aur.1686 132 MaierSDppersALRungeKDackoMLangeTFangmeierTet al

& Maimets, T