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Pregnant or breastfeeding individuals and minors should avoid these therapies, and anyone considering peptides must complete a thorough medical evaluation first

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However, people who are at risk of deficiency will probably need to take supplements

If the pathology involves lip, alveolus, and palate (e.g., complete cleft of primary and secondary palate), orthodontic consultation is needed for nasoalveolar molding, otherwise only nasal molding is performed by a plastic surgeon with silicone conformers

Long-term safety monitoring includes periodic laboratory testing, but the medication appears safe for extended use in appropriate candidates

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