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In differentiated cells, high levels of DNA methylation occurred in the CpG-rich promoters of pluripotency-related genes (Shi et al., 2008)

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A public comment period is open through June 29, 2026

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Systemic safety in prolonged use remains understudied, particularly regarding copper bioaccumulation or immune effects

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Ozempic and Wegovy are both semaglutides

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This is progressive loss of medication effectiveness despite maintained dosing

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