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In this Review, we discuss the mechanistic differences between telomere maintenance by telomerase and ALT, the current methods used to detect each mechanism, the utility of these tests for clinical diagnosis, and recent developments in the therapeutic strategies being employed to target both telomerase and ALT

The total number of unique peptides for each cell line are shown (Supplementary Fig

Many seniors also benefit from structured weight loss programs that combine medication with dietary coaching and physical activity adapted to mobility and joint health

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The snx1/snx2a/snx2b triple mutant shows slightly more pronounced defects in overall growth but displays negligible phenotypic changes during embryonic development (Fig

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