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In the absence of a target, structure-activity work is constrained to behavioral and EEG endpoints, which are too noisy and too downstream to discriminate between plausible mechanistic hypotheses

The one controlled insomnia trial showed modest effects at best

S., OMalley, G

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[,,] Mania in bipolar disorder is linked to mitochondrial hyperactivity, while the depressive and euthymic phases are related to mitochondrial underfunction

Taking these together ensures that neither antioxidant goes to waste