Children born to two carriers, have a 25% chance of being homozygous dominant (unaffected), a 50% chance of being heterozygous (carrier), and a 25% chance of being homozygous recessive (affected)
35 Under normal circumstances, islet beta-cell morphology is characterised by a large and stable number of intracellular mature insulin vesicles, which is sustained through the balance between biosynthesis, degradation and secretion
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