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In mammalian cells, glutathione primarily exists in the reduced state at moderate concentrations and in an extremely high proportion, effectively scavenging reactive intermediates produced spontaneously by cells or from external toxic factors, thereby protecting the cells

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Smokers melanosis: Smokers melanosis is a specific entity characterized by black-brown hyperpigmentation of the oral cavity of heavy smokers[91]

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For example, the medial nucleus has a greater concentration of ascorbate in the hypothalamus than in either the preoptic nucleus or the posterior nucleus (Mefford et al., 1981)