retatrutide weight loss efficacy New Phase 3 data just dropped 👀 Eli Lilly's trial reported average approaching 30%, with some patients achieving results historically associated with bariatric surgery. A few important caveats Retatrutide just cleared 20% weight

many patients are getting prescriptions from primary care doctors rather than weight-management specialists

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

As it relates to our conversation and I think writ large the whole field, youre hearing a lot, a lot more about different mechanisms

518 Studies indicate that liraglutide may inhibit liver carcinogenesis through its metabolic effects, suggesting that GLP-1RAs could potentially play a role in preventing or managing HCC in the context of NASH

Zepbound (tirzepatide) acts as a "dual agonist," targeting both GIP and GLP-1 pathways

I had to do the walk of shame and get off the roller coaster and let my 7-year-old ride it with his cousin, Wysock, an elementary school teacher and married mother of two, said of the 2022 incident