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BMJ, 389, r1344

Muscle biopsy of this child showed a significant increase in glycogen in the muscle fibers and ultrastructural cylindrical helices in the submuscular region

Key metrics to track: Time to fall asleep (sleep latency) Number of nighttime awakenings Deep sleep percentage (if using a wearable) Morning alertness and energy Daytime cognitive performance Stress and cortisol management DSIP's effects on the HPA axis and cortisol regulation suggest potential benefits for stress-related sleep problems

Zepbound (the same drug) is FDA-approved for obesity

Patients switching from Wegovy to orforglipron had a change of -0.1 kg versus a 9.4 kg gain for placebo

In sepsis, pathophysiological changes include sympathetic nervous system activation, and excessive release of catabolic hormones (catecholamines and glucocorticoids) and pro-inflammatory cytokines