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In further accordance, the tested agents (i) increase, rather than decrease, and water intake, (ii) block alcohol-induced hyperlocomotion and dopamine release in NAc which are parameters unaffected by aversion, and (iii) attenuates drug-related responses that are driven by reward rather than by malaise [for review see (115)]

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Acknowledgments We thank Haiyan Yu, Xiaomin Zhao and Yuyu Guo from Core Facilities for Life and Environmental Sciences of SKLMT (State Key Laboratory of Microbial Technology, Shandong University) for the assistance in LSM900 Super Resolution Laser Scanning Confocal Microscope analysis