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Drug-induced acute liver failure is a fatal disease thats caused by the toxic metabolite N-acetyl-p-benzoquinone-imine that leads to glutathione depletion

Alveolar macrophages derived from circulating monocytes recruited into the lungs by monocyte chemotactic factors produced by lung cells are increased 20-fold in COPD patients and release ROS as superoxide anions and hydrogen peroxide (102)

doi: 10.1039/b9nr00178f

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The liver does not function as a merely passive filtration organ that mechanically sequesters circulating debris