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Gut inflammation and barrier dysfunction may facilitate -synuclein misfolding in the enteric nervous system, with retrograde propagation via the vagus nerve (Li et al., 2023

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CHAC1 upregulation has been shown to be associated with the suppression of SLC7A11 and NRF2 and a surge in lipid peroxidation

J Reprod Dev (2019) 65:13946

In mouse models of E/I dysfunction, GABA_B receptor agonists like arbaclofen have been shown to restore aspects of the E/I balance, resulting in improved behavioral deficits ( Histopathologically, while GABA supplementation helped in preserving some aspects of hippocampal structure, significant neurodegeneration and reduced neuron density remained, particularly in the CA4 region, similar to what was observed in the PPA-treated group