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It depends on the type of pigmentation you are treating & other therapies that are initiated

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10.3389/fped.2014.00066 15 FryeR

Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics

This can be a network of interconnected evidence previously envisaged in the implementation of the cytoprotection effects (see Figure 1)