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Hypoglycemia risk increases when tirzepatide is combined with insulin or sulfonylureas, though the medication alone rarely causes low blood sugar due to its glucose-dependent mechanism

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Side Effects Similar to existing GLP-1 drugs, the primary side effects are gastrointestinal

nausea ~42%, diarrhea ~32% compared to ~15% and ~14% respectively in placebo), I wonder if the discontinuation is more related to the side effects, nutritional factors, social acceptance with eating behavior or other parameters, rather than excess weight loss per se