glp-1 and dpp4 together Inhibitors vs Agonists | June 2021 | Clinical Corner Effects of GLP-1 and DPP-4

268 Sensenig, J., Johnson, M

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Cognitive function in obese individuals improves substantially with weight loss alone, but the direct central GLP-1R effects may contribute additional benefit beyond what weight reduction alone would predict

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Targeting lipid peroxidation and mitochondrial imbalance in Friedreichs ataxia

Perhaps more importantly for tolerability, GIP activation seems to buffer against the nausea commonly caused by GLP-1 stimulation alone