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These include pancreatitis, gastroparesis, gallbladder and biliary disease, and, in select cases, acute kidney injury related to dehydration

Furthermore, osthole inhibited the activation of the TGF-1/Smad signaling pathway, which is implicated in endothelial dysfunction (Wang et al., 2018)

It works synergistically with the cytochrome P450 system, which is responsible for metabolizing drugs and other substances through "Phase I" (e.g., oxidation and reduction reactions), imparting certain polarity and reactivity

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Neurotoxicology 28:161167