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However, they also represent peak incidence, and most people find that their GI system adapts over the first four to eight weeks at the maintenance dose

Every comparative claim in this article therefore carries a caveat: it is either an indirect comparison across trials with different populations, dosing schedules, and endpoints, or it is a mechanistic extrapolation from preclinical and Phase 2 data

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Providers only advance patients who show consistent tolerability and a clinical reason to increase further

However, Mathiesen et al