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Neuroinflammation Neuroinflammation is increasingly recognized as a key factor interacting with neurobiological correlates of the neuropsychiatric long COVID syndrome, such as brain serotonin depletion [111], hypothalamicpituitaryadrenal (HPA) axis dysregulation [57], and impaired hippocampal neurogenesis and plasticity [13, 61]

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The commenters noted that the cost of the procedure exceeds payment by approximately $4,000 and expressed concern that this discrepancy would result in patient access to the procedure being limited, particularly considering that the alternatives for severe emphysema patients involve much more invasive and expensive treatment options