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Hankosky ER, Wang H, Neff LM, Kan H, Wang F, Ahmad NN, Griffin R, Stefanski A, Garvey WT

The STEP 4 withdrawal trial demonstrated that discontinuation of semaglutide 2.4 mg after a 20-week run-in is followed by nearly complete weight regain within one year an outcome that is more accurately framed as disease recurrence in a chronic relapsing condition than as drug failure (Quimbayo-Cifuentes, 2026)

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Among these, CJC-1295 stands out as a synthetic analog of Growth Hormone-Releasing Hormone (GHRH)