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At the intestinal level, TMAO can downregulate tight junction proteins, such as Claudin-1, alter the Firmicutes/Bacteroidetes ( F/B ) ratio, reduce the microbiotas resilience to stress, and promote the elevation of harmful metabolites, thereby inducing systemic inflammation (Chen et al., 2022)

For hematocrit and reticulocyte counts, recommendations are to repeat these tests daily from the 5th to 7th days of treatment and then frequently until the hematocrit returns to a normal range (11, 14, 15)

PLoS ONE 10(11):e0141706 Ricchi P et al

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The localized nature of hydrogel delivery confines immune modulation to the tumor site, minimizing systemic immune-related adverse effects and enabling high local efficacy with improved safety

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