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In the Phase 3 REDEFINE 1 trial, cagrilintide monotherapy achieved 11.8% average weight loss over 68 weekscomparable to semaglutide but with a notably lower incidence of nausea and vomiting, making it a potential option for patients who dont tolerate GLP-1 medications well

Glucomannan is a type of soluble fiber derived from the edible roots of the konjac plant

Storage (Lyophilized): Store at -20C

Target 1.21.6 g/kg body weight (roughly 0.50.7 g/lb)

For pediatric patients or very frail adults, a 5/8 inch needle may suffice

The myotendinous junction studies (Japjec et al., 2021, Biomedicines ) extended the tendon work to the muscle-tendon interface, showing accelerated healing of disabled junctions in rats