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Alternatively, Adenosine, A 2A and A 2B receptors stimulate lipolysis in human brown adipocytes which may represent a novel mechanism of BAT regulation in humans (233)

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MOTS-c, by contrast, works from the inside of the mitochondria outward, activating the same primordial energy-sensing cascade that millions of years of evolution have refined into the body's most fundamental metabolic regulator

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doi: 10.2337/DB16-0616 173 BuschardKJensenMHKrogvoldLGerlingICDahl-JrgensenKPedersenKet al