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4 Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, Peoples Republic of China *These authors contributed equally to this work Correspondence: Tian-Cheng Wang Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, Peoples Republic of China Tel +86 15073190153 Email [email protected] Shi Zhou Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, Peoples Republic of China Tel +86 13809477708 Email [email protected] Objective: To investigate the sustained release of lidocaine from a lidocaineepirubicinlipiodol emulsion created by water-in-oil (W/O) technique in vivo and evaluate the efficacy and safety of intraarterial lidocaine administration for intra- and postoperative pain control in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC)

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IV therapy can have more acute side effects during the infusion (flushing, etc.), but these are manageable with proper administration

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