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The cultures were then sampled at four different growth stages over a period of 30 h ( Figure 6 )

Peter M, Li Z, Shuxuan L, Zihan Z, Tao J, Fei M et al

29 Collectively, these insights reinforce that autophagy is neither merely a degradation pathway nor a binary process but a carefully tuned homeostatic program that determines whether the myocardium adapts or deteriorates under stress

Thus, although E 2 causes genetic changes conducive to its own inactivation, the decrease in estrogenic activity yields a toxicologically active metabolite that constitutes an additional pathway of estradiol-dependent carcinogenesis

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