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Take once daily at the same time each day for best results

The key question will be long-term durability, safety, tolerability, and how these therapies perform in broader real-world populations beyond controlled trials

Medications that require specific absorption timing, particularly oral medications with narrow therapeutic windows, may have altered absorption kinetics

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The Bottom Line Retatrutide represents an exciting advance in obesity treatment, showing the potential for even greater weight loss than the already impressive tirzepatide

Pinch the skin : If advised by your healthcare team or device instructions particularly if you have less subcutaneous fat or are using a longer needle gently pinch a fold of skin and subcutaneous tissue between your thumb and forefinger to lift the fat layer away from the muscle beneath