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Researchers have also demonstrated the harmful effects of the by-products on human health, including protein modifications, protein structure reduction, sugar oxidation into organic acids, unclear lipid and unsaturated fatty acid peroxidation, and disruption of helical structure into amino acids (Jiang et al

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Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation

Cerebral hypoperfusion In addition to abovementioned stroke that causes acute cerebral hypoperfusion, chronic cerebral hypoperfusion due to various systemic conditions is also common in VaD pathogenesis

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