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Conclusion The link between acetaminophen and glutathione depletion is a well-documented biological reality

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Furthermore, thearubigins have been shown to elevate conjugated bile acid levels, suppress the intestinal FXR-FGF15 signaling pathway, reduce cholesterol and fat synthesis, and activate alternative bile acid synthesis pathways to promote fat breakdown (21)

In order to capture this complexity, we have, in collaboration with clinicians and experimentalists, developed mathematical models based on the real underlying physiology [10-16]

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doi: 10.3164/jcbn.11-006FR