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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

If the B12 ingested was part of a multivitamin, then the list of potential sources for a reaction becomes quite formidable

Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness

(STEP 1 Extension) 4

[DOI] [PMC free article] [PubMed] [Google Scholar] 478

The Synthesis of a Tetrapeptide