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47 In that study the composition of progenitors and new neurons that exit the cell cycle was not altered by deletion of TrkB

Madeira F, Madhusoodanan N, Lee J, Eusebi A, Niewielska A, Tivey ARN, et al

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These ligands appear to act as activators promoting (priming) ligand interaction to induce the necessary conformational change in the cytoplasmic tail to trigger signaling 1,2,3,5