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doi: 10.1056/NEJMra1915327 8

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The trade-off: Ipamorelin preserves natural GH pulsatility and is suitable for long-term protocols (12+ weeks), while MK-677 suppresses endogenous pulses through negative feedback and is best reserved for short 46 week maximum stimulus cycles

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Well look at how this tech is used in the LifeWave X39 patch and its effects on the body