This shift is most evident in the beverage category, where prebiotic/probiotic sodas like OLIPOP and Poppi are leading the shift away from traditional sugary beverages, but extends across multiple categories as consumers seek digestive benefits at the meal level, not just from supplementary products
The redox inactivation of SAL1 promotes the transport of PAP from chloroplasts (and mitochondria) via PAPST transporters to the nucleus where it inhibits exoribonuclease-mediated RNA metabolism (Figure 2 and Supplementary Table 3)
Alternative approaches include lifestyle modification, dietetic support, resistance exercise, and consideration of orlistat or bariatric surgery where appropriate
The drug mimics the action of thyroid hormone and cranks up fat metabolism in the liver
What benefits are realistic, and what outcomes remain unproven
Patients using non-oral contraceptive methods (intrauterine devices, implants, injections, patches, or vaginal rings) are not affected by these absorption concerns, as these methods do not rely on gastrointestinal absorption