A similar study published in The Lancet corroborated this finding when researchers found the lowest levels of glutathione were found in the elderly sick
This is primarily relevant for HSC70 (Roperto, 2022), although BAG3 has also been shown to associate with HSPA1A, increasing its activity (Xia et al., 2025) or together with HSP70, as shown by Ruggiero and colleagues reporting the first known inhibitor targeting both BAG3HSP70 (Ruggiero et al., 2025)
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Trends Genet 35 , 215222 (2019)
