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This can include the use of GLP-1 medications, which have been shown to promote weight loss and offer additional health benefits such as reduced inflammation, improved glucose control for those with type 2 diabetes, and reduced cardiovascular risk factors
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A notable safety signal is dysaesthesia, which refers to tingling, numbness, or altered skin sensations, reported in about 1 in 5 participants at the 12 mg dose
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2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026