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Until rigorous clinical trial data become available, any use of tirzepatide for BED remains speculative and off-label, requiring careful consideration of the risk-benefit profile in individual patients

All three GLP-1 analogs reduced body weight by 2.7 to 3.7 kg, with exenatide and exenatide LAR inducing similar weight loss and liraglutide inducing greater weight loss than both exenatide and exenatide LAR [17,19,76]

During the final four weeks, the ApoE / mice were divided into four groups (6 mice per group), including control (PBS, ip, twice daily), metformin (100 mg/kg per day, via drinking water

The mechanism of 6-paradol's thermogenic activity is activation of brown adipose tissue (BAT)

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