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In contrast, systemic inhibition of DPP-4 activity reduced lipid excursion and increased active GLP-1 levels in both genotypes (Figure 3, AD)

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In the standard dosing group, HbA1c was significantly lower at 3 months (median HbA1c 8.1%, IQR 6.98.6

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Matrixyl (palmitoyl pentapeptide-4) targets the same collagen-stimulation endpoint but through a different mechanism and is five amino acids rather than three

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