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Ultrasound assessment of muscle mass and correlation with clinical outcomes in critically ill patients: a prospective observational study

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Factors affecting response time include baseline GH/IGF-1 levels, age (older people may show greater responses), training and nutrition protocols, dosing frequency and consistency, sleep quality and stress care, and personal genetic factors

However, the authors noted that the available evidence was limited by small study populations, short durations, and differences in dosage and formulation

Moreover, ROS exerts an important effect on microglia as the second messenger, modifying inflammatory gene transcription and, consequently, amplifying the inflammation

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